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Cell culture Normal human epi-dermalkeratinocyte (NHEK), human immortalized epidermal cells (HaCaT) cell, RAW 264.7 cell were sourced from the Shanghai Institute of Cell Biology of the Chinese Academy of Sciences

Patient samples and CAR T cell therapy De-identified clinical samples were collected from a subset of adult patients with relapsed/refractory B-ALL who received investigational CD19-specific CAR T cells in a phase 1/2 clinical trial (NCT02146924) at our institution 29

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