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It is not clear whether the replacement of melanocytes of the basal cell layer of the oral epithelium lost to physiological processes of apoptosis or senescence, or to mechanical, thermal, or chemical injury is the result of cell division of mature melanocytes in the basal cell layer of the oral epithelium which still retain their capacity of replication, or a result of migration from their local niche reservoirs of melanocyte stem/progenitor cells and their subsequent proliferation [6]

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The findings are scheduled to be published in the April issue of the international journal 'The Lancet Psychiatry'

Your goal should influence which dosage level you target and how aggressively you escalate