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There are individuals who have a guilt around taking a drug to lose weight, as they consider this a personal failure
Currently, tirzepatide is the clear choice for type 2 diabetes because it has FDA approval for this indication and extensive clinical evidence
249 Nuclear STAT3-Y705 activates glycolysis and fatty acid oxidation (FAO) genes, while mitochondrial STAT3-S727 and acetylated STAT3-K685 impair oxidative phosphorylation by destabilizing electron transport chain (ETC) complexes, supporting leukemia stem cell dormancy and persistence
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