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, enables macrophages to heal, T-cells to form memory), whereas mitochondrial dysfunction skews toward either hyper-inflammation (if DAMPs are released) or hypo-inflammation (if energy failure leads to cell exhaustion) ( 2.1.3.7 Surgery recapitulates metabolic syndromes There are parallels between the immune metabolic changes in surgery and those in other conditions for instance, the cytokine storm and subsequent immune exhaustion in severe COVID-19 or sepsis have similar roots in mtDAMPs release and metabolic collapse

FIGURE 2 Recent investigations by Jin et al

GPX4 is one of the major functional enzymes of glutathione peroxidase