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This limitation is attributed to issues such as low solubility in the gastrointestinal environment and significant first-pass metabolism (Chang-Liao et al., 2012

Exp Neurol 150:4044 Sofic E, Lange KW, Jellinger K, Riederer P (1992) Reduced and oxidized glutathione in the substantia nigra of patients with Parkinson's disease

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