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Subsequently, caspase-1 is activated, which in turn cleaves Gasdermin D (GSDMD), leading to cell membrane perforation and release of interleukin-18 (IL-18) and IL-1, ultimately resulting in cell swelling and pyroptosis (Liu et al., 2024)
GLP-1 RAs have been found to have vasodilatory and anti-atherosclerotic effects in animal models and some human studies
In June of 2021, the FDA approved Wegovy (semaglutide), a weekly injectible
More adults receiving tirzepatide achieved 5%, 10%, 15%, 20% and 25% weight reduction compared with placebo across all three disease duration groups
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