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Neurotrophins such as BDNF and NGF play central roles in synaptic plasticity, neuronal survival, and network organization, and their dysregulation may represent a more proximal mechanism underlying behavioral impairments
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But several factors work against this natural recovery process, including age (collagen production drops roughly 1% per year after age 20), the amount of weight lost (more than 50 pounds creates significantly more laxity), how long the excess weight was carried, sun damage history, smoking, genetics, and the speed at which the weight came off
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Beltramo, E., Berrone, E., Tarallo, S., & Porta, M
