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Published peer-reviewed research has established several mechanisms through which these medications support weight management: they help reduce appetite by acting on hunger signals in the brain, they slow gastric emptying - which promotes a feeling of fullness after meals - and they help regulate post-meal blood sugar responses
There is considerable interest in the potential to combine GLP-1RAs with SGLT2is because their mechanisms of action are complementary with regard to target organs, disease processes [31], and the effects seen in cardiovascular/cardiorenal outcomes trials [23,24,25,26,27,28,29, 32,33,34,35,36]
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They can be worse when starting treatment or going up a dose
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