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The oxidized form (GSSG) is essentially "spent" and must be recycled by the body using energy before it can become useful again
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase
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However, since mitochondria are also a major site for metabolomic regulation, problems or dysregulation of metabolites are now gaining attention, especially for motor neuron diseases, which display mitochondrial problems as one of the early cellular pathologies
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