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If this fuel-partitioning model of obesity is correct, then its quite likely that the GLP-1 drugs work by reversing this fat-trapping process, unlocking fat stores
Winfrey started taking GLP-1 medication in 2023, then took a one-year break from 2024 to 2025
Patients tracking bloodwork biomarkers should add fasting insulin and HOMA-IR to their TRT panel
The STEP UP trial, a Phase 3b study published in The Lancet Diabetes & Endocrinology in 2025, evaluated a 7.2 mg weekly injection dose in over 1,400 adults with obesity (BMI of 30 or higher) and without diabetes
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