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Abdominal distension, or swelling Abdominal pain Burping (eructation) Constipation Diarrhea Dizziness Dyspepsia, or upset stomach Fatigue Gas (flatulence) Gastroenteritis Gastroesophageal reflux disease (GERD) Hair loss Headache Heartburn Hypoglycemia Nausea Vomiting These side effects may appear mild at first, but they can escalate in severity or because of symptoms of more serious side effects
Ohio State notes that GLP-1 medications can lower both appetite for food and thirst for liquids, while Wegovys official side-effect pages specifically mention fatigue as a common side effect
Diabetologia 61 , 284294 (2018)
One study reported the presence of GLP-1R on the membrane of human liver cells, which undergoes endocytosis following GLP-1RA stimulation and acts by regulating downstream molecules of insulin signaling
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