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Description

UT Southwestern Medical Center

Dealing with side effects is a major issue

The review revisited SUSTAIN-6, where semaglutide-treated patients showed a hazard ratio of 1.76 for retinopathy complications compared with placebo. The discussion has since shifted toward whether rapid metabolic changerather than direct retinal toxicitymay explain the signal

Overall, clinical trials showed starting with a lower dose of around 2 mg can reduce the intensity and frequency of GI side effects, compared to a higher initial dose (4 mg)