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Okuma et al
The findings are intriguing because they align with what weve seen in preclinical models and some human studies: GLP-1RAs appear to reduce neuroinflammation, improve insulin signaling in the brain, and potentially slow processes associated with cognitive decline, he noted
Immunostaining was performed by seeding cells on glass coverslips, fixing with paraformaldehyde, permeabilizing with Triton X-100, and then incubating with primary anti-NF-B p65 antibody, followed by Alexa Fluor 546-conjugated secondary antibody
Glucagon-like peptide-1 (GLP-1) receptor agonists were originally developed to treat people with type 2 diabetes, entering clinical use in the mid-2000s
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