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coli , cysteine is synthesized from serine through the serine acetyltransferase CysE, which converts L-serine to O-acetyl-L-serine (OAS), and the O-acetylserine sulfhydrylase CysK

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They are not interchangeable, and the more interesting question is not "which wins?" but "do they reinforce each other?" This article compares the two on mechanism, evidence, and practical use and then examines the documented and theoretical basis for combining them, including the important safety limits