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This pKa, usually around 9, is lowered to approximately 6.5 or even less, promoting the formation of a nucleophilic (reactive) thiolate group in vivo , which is able to perform a nucleophilic attack on a nearby electrophilic substrate
Nature of glutamate alterations in schizophrenia: a meta-analysis of proton magnetic resonance spectroscopy studies
Yuan C, Yu C, Sun Q, Xiong M, Ren B, Zhong M, et al
Animal studies involved naturally aged male C57BL/6 mice that were 20 months old and younger controls that were 3 and 13 months old
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