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These preliminary findings warrant further investigation in larger, placebo-controlled trials in order to more rigorously assess the safety, efficacy, and translational potential of this intervention for mitigating chronic cognitive sequelae in individuals with moderate to severe TBI
A negligible fraction of cells were propidium iodide + alone, indicating that X(PC) does not merely initiate unprogrammed necrotic cell death in SUP-B15 cells but rather directly activates a pyroptotic lytic death through caspase activation
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