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Pegloticase (trade name Krystexxa), is also a tetrapeptide that is an intravenous drug used to treat hyperuricemia in patients that do not respond well or cannot tolerate other forms of gout treatment.
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Cloning and mutagenesis The gene for full-length COP1 (residue M1-V731) was codon optimized and synthesized by GENEWIZ
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