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334 TAMs deprived of TNF signaling retain high expression of hematopoietic PGD2 synthase (HPGDS), continuously secreting prostaglandin D2 (PGD2), which reinforces macrophage immunosuppressive identity and directly inhibits CD8 T-cell cytotoxicity
CONCLUSION The use of taxane-based treatments was increased over time in patients with breast cancer
These outcomes align with the peptides mechanisms: it stimulates collagen and elastin production , enhances matrix renewal, and reduces inflammation
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