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160(2):389 to 393., Original discovery of the erectogenic effect

Understanding why they happen takes away a lot of the worry, and knowing what genuinely helps means you don't have to just wait them out, and it means these symptoms don't have to derail your Mounjaro weight loss results

Administered as a once-weekly subcutaneous injection, it works by mimicking the action of the naturally occurring hormone GLP-1, which stimulates insulin secretion in response to elevated blood glucose levels, suppresses glucagon release, and slows gastric emptying

Side Effects Comparison# Retatrutide Side Effects# Phase 2 data (n=338 obesity trial): Nausea : ~25% at higher doses (8-12 mg) Diarrhea : ~20% Vomiting : ~15% Constipation : Common Decreased appetite : Common (pharmacological effect) Heart rate : Small increase (2-4 bpm), potentially related to glucagon component Injection site reactions : Mild, transient Discontinuation rate : 6-10% due to adverse events The glucagon receptor component introduces theoretical concerns for hyperglycemia (counterbalanced by GLP-1/GIP in practice), cardiovascular effects (chronotropic glucagon action), and hepatic effects, none of which produced safety signals in Phase 2 but require larger-scale monitoring