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This deleterious effect could depend on a shift in proteasome composition from classical to immunoproteasome subunits, a phenomenon known to play a role in the neurotoxicity observed in neurodegenerative diseases, and on an increase in chymotrypsin-like and trypsin-like activities (Pla et al., 2014)

Treatment of cultured parasites with sublethal levels of AF and TGR dsRNA showed an additive effect significantly accelerating the killing of schistosomula compared to RNAi or AF treatments alone (Figure 7C)

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