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However, hyperpigmentation often does not respond to topical treatments alone
This is not failure but appropriate medical treatment for a severe condition
Arch Androl 39:3044
Research showed that T4 reversed the expression of pro-apoptotic factors (cleaved caspase-3 and caspase-9) that drive liver cell death, a process that leads to fibrosis and cirrhosis if it continues unchecked [10]
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