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In addition, gene therapy based on transfection of mtDNA-complexed TFAM or recombinant TFAM to PD cybrid cells shows potential to restore mitochondrial bioenergetics of severely impaired nigral neurons, as TFAM is important for mtDNA maintenance (Keeney et al., 2009
This structural modification significantly extends its half-life and enhances resistance to proteolytic degradation, thereby enabling prolonged biological activity in vivo
Unknown long-term profile: Long-term human safety data is limited
Retatrutide remains investigational, and the Phase 3 TRIUMPH program is the key regulatory pathway to watch
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