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23 The importance of autophagy extends to cardiac development, as evidenced by embryonic lethality and myocardial developmental defects in Atg13-knockout mice, underscoring the indispensable roles of Atg13 and FIP200 in both autophagy and heart formation (Fig

doi:10.1089/thy.2016.0256 Grtner R, Gasnier BC

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Clinicians often integrate the product with calorie-restricted diets, resistance training, and behavior-change counseling to potentially maximize adipose mass reduction while preserving lean tissue, though evidence remains largely extrapolated from the individual components pharmacology and not from randomized controlled trials of the exact compounded combination