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By analogy with semaglutide (where the STEP-4 withdrawal trial demonstrated substantial weight regain within 12 months of discontinuation), researchers should anticipate that weight regain is likely following cessation of any GLP-1 class compound, including retatrutide
And the research supporting this delivery method, while promising, comes with important caveats that every informed researcher should understand before making the switch
Enhanced tissue healing, reduced inflammation, and improved surrounding tissue health may collectively improve function even if the disc itself remains unchanged
JAMA 323 (19), 193444 (2020)
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