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In CRC, combining 5FU with DNA-damaging agents oxaliplatin and/or irinotecan was an empirical choice rather than a rationally designed strategy, and no new combination partners have been added since the introduction of the biological EGFR and VEGF-targeting agents in the early 2000s

doi: 10.1016/j.cmet.2022.08.003 100 RicciALieszA