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4 Effect of MK-677 on mRNA and protein expression of growth hormone (GH), GH-releasing hormone (GHRH), GH secretagogue receptor (GHSR), somatostatin (SST), somatostatin receptor (SSTR)-2, and SSTR-5 in the hypothalamus or pituitary gland
What to Expect: Energy, Recovery, and Metabolic Changes When Do Results Start
For patients whose primary goal is fat loss and body composition improvement: Ipamorelin may be preferred due to its selective GH stimulation without cortisol elevation Cortisol is directly antagonistic to fat loss, particularly visceral fat The clean GH pulse from ipamorelin supports lipolysis without metabolic interference Sermorelin also supports fat metabolism through sustained GH improvement The best approach depends on individual factors including baseline hormone levels, cortisol status, and treatment goals
Saxena et al., 2021)
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