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Side Effects and Tolerability The dominant side effects of both amylin analogs and incretin agonists are gastrointestinal : nausea, vomiting, diarrhea, and constipation

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329,330 In degenerative joint diseases like OA, the metabolic balance of chondrocytes is disrupted, leading to the overproduction of degrading enzymes and inflammatory mediators, including iNOS, MMP-13, and ADAMTS5 (a disintegrin and metalloproteinase with thrombospondin motifs 5), which participate in cartilage degradation and inflammatory processes