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thus, the choice of the dose will likely depend on metabolic targets [22]
It is usually a small, well-chosen combination, often built around metformin if eGFR allows, layered with an SGLT2 inhibitor and possibly a GLP-1 receptor agonist, with insulin reserved for when those options are not enough
You will never start at the highest dose
What they do is address the appetite and metabolic compensation mechanisms that make weight loss difficult regardless of thyroid status
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