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Targeted delivery to peripheral nerves remains challenging due to the blood-nerve barrier, and off-target effects can pose safety risks
This allows researchers to simulate acute, natural physiological pulses rather than continuous elevation
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For patients inadequately controlled on sitagliptin monotherapy: For patients inadequately controlled on sitagliptin alone, the usual starting dose of SITAGLIPTIN PHOSPHATE + METFORMIN HCl (JANUMET) is 50 mg sitagliptin/500 mg metformin hydrochloride twice daily
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