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Furthermore, it increases the risk of osteoporosis and fractures, especially in post-menopausal women,83 and its extended use has been associated with a potential increase in bladder cancer.84 In conclusion, although pioglitazone can be used for any degree of CKD, its adverse effects (oedema, heart failure, fractures, risk of bladder carcinoma) limit its indication in patients with the aforementioned disease
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It works as a binder, film former, and viscosity increasing agent
However, severe side effects like an inflamed pancreas or an allergic reaction will require immediate medical attention
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