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Both primary and metastatic CNS neoplasms, the most common of which in adults are astrocytomas, oligodendrogliomas, and mixed oligoastrocytomas, 119 are difficult to treat because most chemotherapeutic agents are unable to adequately traverse the BBB as a result of their low lipophilicity

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An individual with ASD will usually also prefer to stick to a set of behaviors and can resist any significant (or numerous minor) modifications to day-to-day activities

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