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Alcohol is worth mentioning specifically

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Seek immediate medical attention (call 999 or attend A&E) if experiencing: Seizures or convulsions of any type, particularly if this is a new occurrence Loss of consciousness or fainting episodes Severe, sudden-onset headache unlike previous headaches, especially if accompanied by visual changes, neck stiffness, or confusion Symptoms suggestive of stroke , including sudden weakness, speech difficulties, facial drooping, or visual disturbances Severe hypoglycaemia symptoms with confusion, inability to concentrate, or altered consciousness (particularly relevant for patients on insulin or sulphonylureas) Severe, persistent abdominal pain (especially if radiating to the back) stop taking Wegovy and seek urgent medical attention as this could indicate pancreatitis Contact your GP or prescribing clinician within 24 hours for: Persistent or worsening headaches that do not respond to simple analgesia Recurrent dizziness affecting daily activities or balance Visual disturbances including blurred vision or changes in vision (noting that diabetic retinopathy complications have been reported with rapid glycaemic improvement) Unexplained confusion or cognitive changes Severe, persistent gastrointestinal symptoms (vomiting, diarrhoea) that may lead to dehydration If you need urgent advice and it's not life-threatening, contact NHS 111

Some patients who cannot tolerate semaglutide do well on tirzepatide, and vice versa