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To understand which step of Wnt/-catenin signaling is affected by NTAPP, experiments using two inhibitors for Wnt/-catenin signaling pathway were performed
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We believe that one of the important mechanisms underlying this effect is likely reduction of inflammation in the fatty tissue around the heart, which we know is an important driver of arrhythmias and other unwanted cardiac outcomes. Bilchick plans to continue investigating these inflammatory mechanisms in collaboration with UVA immunology researcher Coleen McNamara, UVA MRI physicist Frederick Epstein (who developed an MRI method to characterize fatty tissue surrounding the heart), and UVA Director of Cardiac Imaging Amit Patel
