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However, the same Authors in the second study, failed to demonstrate a reduction in HOMA-IR, fasting glucose and insulin and glucose and insulin during OGTT in both treated groups [58]

Where they diverge is the specific medication menu, membership tiers, provider model, and published pricing

The key difference: retatrutide activates three receptors (GLP-1, GIP, and glucagon) while tirzepatide activates two (GLP-1 and GIP)