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Poor sleep increases ghrelin (hunger hormone) and decreases leptin (satiety hormone), directly undermining dietary adherence
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Research in this area is ongoing
Key variants in GLP1R (the GLP-1 receptor), GIPR (glucose-dependent insulinotropic peptide receptor), FTO (fat mass and obesity-associated gene), and MC4R (melanocortin 4 receptor) may affect medication sensitivity, baseline hunger signaling, and metabolic rate
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