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It seems safe to conclude that the phenomenon of early worsening of pre-existing Diabetic proliferative retinopathy was secondary to the initial and rapid improvement in glycemic control that occurred in SUSTAIN-6

Additionally, regular blood sugar monitoring and management are critical to help minimize the risk of serious eye problems that may be associated with the drug

Findings suggested that BPC157 exposure was associated with upregulation of VEGFR2 at both mRNA and protein levels, and with downstream activation of the phosphatidylinositol 3-kinase (PI3K)-Akt-eNOS signaling cascade