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Apart from A plaques and NFTs, other pathological features of AD include neuroinflammation and microglial activation, synaptic dysfunction, reduced cerebral glucose metabolism, astrocyte activation, and neuronal loss [4]
Early human safety work suggested AOD-9604 was generally well tolerated, with a placebo-like adverse-event profile and no IGF-1 elevation [5] [6]
Modeling based on current utilization suggests these price reductions could generate $932.7 million in savings, sufficient to offset treatment costs for approximately 550 000 additional beneficiaries eligible for expanded #obesity coverage
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