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The condition was considered occupational in only 1 patient, a clinical assistant who worked in a PDT unit.6 Some authors have reported severe reactions with dissemination that occasionally required hospitalization and treatment with systemic corticosteroids.13 Others reported less severe, localized reactions.6 Patch tests with Metvix as is were positive in all patients and, in the 19 patients who underwent them, patch tests with the vehicle were negative

Importantly, GIP expression was found in neurons of all major brain regions, including the cortex, hippocampus, the amygdala, and midbrain areas such as the substantia nigra (SN) [114]

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