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Several studies point to a protective role of GLP-1RAs on retinal pigment epithelium (RPE) cells, which form the blood-retinal barrier and are vulnerable to inflammation [83, 84]
A GLP-1 and GIP analogue should only be offered to adults with T2DM, in combination with insulin with specialist care advice and ongoing support from a consultant-led multidisciplinary team
Then theres tirzepatide, sold as Zepbound and Mounjaro, which mimics not only GLP-1 but also glucose-dependent insulinotropic polypeptide, or GIP
Activation of GHRH receptors results in the opening of a sodium channel in the somatotrope, leading to its depolarization
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