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The statistical analysis was performed using XLStats 2017 software (Addinsoft, New York, NY)
This variability likely reflects differences in study populations, such as the presence or absence of T2DM, degree of obesity, sex distribution, and comorbid conditions, as well as differences in intervention characteristics, including the type, dose, and duration of GLP-1 RA therapy
GDMT for HFrEF typically includes evidence-based beta-blockers, angiotensin receptor neprilysin inhibitors (ARNIs), angiotensin receptor blockers (ARBs), angiotensin-converting enzyme (ACE) inhibitors, mineralocorticoid receptor antagonists (MRA), and sodium-glucose cotransporter 2 inhibitors (SGLT2is), particularly in patients with obesity or T2DM [53]
Many subjects with oral mucosal melanin hyperpigmentation, whether physiological or pathological in origin, are usually unaware of it so cannot give information about its duration or progression
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