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A stable, consistently cold spot is what you need to preserve the peptide's structure for months or even years
Whether a given study design benefits from synchronising with that pulse, or deliberately offsetting it, depends on the readout being measured, because the timing affects whether the exogenous GH signal amplifies or dampens the endogenous pulse
This is convenient for patients who prefer fewer injections compared to daily treatments like liraglutide (Victoza)
The clinical studies showing efficacy used concentrations in the range that produces measurable results without irritation
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