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In line with evidence from GLP-1RA studies, tirzepatide exhibited a stabilizing effect on UACR, leading to a least square mean difference of 31.9 (95% CI 37.7 to 25.7) mg/g with insulin glargine [49]
However, nausea is the most commonly reported adverse effect, with incidence varying by medication and dose: approximately 15-30% for most GLP-1 agonists and up to 30-44% at higher doses of semaglutide and tirzepatide according to FDA prescribing information
Overall, this seems to have a positive effect, Ali says
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