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Canaglifozin, dapaglifozin, and empaglifozin are the active substances approved in Europe and the USA as second-line treatment in association with metformin as well as third-line treatment [33]
Normal, reduced as well as increased insulin sensitivity have been reported in GH deficient patients (55, 56)
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10.1016/j.cmet.2018.03.001 86
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