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Cerebellum (2011) 10:438.10.1007/s12311-010-0223-4 108 AdamsJBAudhyaTMcDonough-MeansS

How 5-Amino-1MQ works, and why route is being debated at all 5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) , a cytosolic enzyme that transfers a methyl group from S-adenosylmethionine (SAM) onto nicotinamide (a form of vitamin B3), producing 1-methylnicotinamide

These events occurred mainly during the early phase of treatment when the dose was being titrated up