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One small study in nondiabetic patients noted a 6.5% weight loss with sitagliptin versus 7.65% with metformin, but larger trials in type 2 diabetes have not shown a direct effect on body weight
Why it matters for body composition: Smaller fat cells mean less inflammation and better insulin sensitivity, two key components for losing fat while preserving muscle
It can be taken at any time of day and can be taken with or without meals
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