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For instance, the Taiwanese database in Kornelius 2024 included 324,506 subjects, the Nordic (Sweden and Denmark) active-comparator new-user study enrolled 298,553 patients, and the UK study by Shapiro 2025 included 270,110 patients with type 2 diabetes

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Some of the so far reported short-term effects are accumulation of toxins on the skin, irritation, (micro) inflammation, oxygen deficiency, clogging of pores, impairment of skin barrier, dryness / lack of moisture, excessive desquamation, pigment spots, altered metabolism as well as protein, lipid, and DNA oxidation