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Subjects who show no response at 1.0mg likely have MC1R polymorphisms (common in individuals with red hair and Fitzpatrick Type I skin) that prevent receptor activation regardless of dose
Kang SS, Wong PWK, and Malinow MR (1992)
Medical conditions like gastroenterological disorders may hinder B12 absorption
A 2-year observational study that included 168 CKD patients demonstrated that participants with the lowest vitamin D levels had a faster rate of CKD progression and shorter time to kidney failure and death
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