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(Table 1) Targeting glucose metabolism Dapagliflozin is a member of the sodium-glucose co-transporter 2 inhibitor (SGLT2i) family, which can downregulate intracellular glucose levels and upregulate the NAD + /NADH ratio

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The proteolytically active DPP-4 homodimer is found in two forms: a single-pass type II integral transmembrane protein and a soluble protein stripped of any membrane spanning regions or intracellular regions [16]