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Along with mitochondria, synapses are considered end effectors of many molecular mechanisms related to ASD, and the convergence of different neurodevelopmental pathological mechanisms on synapses can at least partially explain the behavioral similarities in different individuals on the spectrum

LA, SH, and JE reviewed and edited the manuscript

The accelerated approval was granted based on initial overall response rate (ORR) of 57% in 164 treatment-nave patients and duration of response (DOR)40% of responders had a duration of response greater than 12 months, according to the FDAs full approval announcement

Neurobiological effects of intraventricular propionic acid in rats: possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders