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If response is inadequate after the FDA-recommended evaluation period at therapeutic doses, consider switching to an alternative agent or referring for surgical revision evaluation in appropriate candidates

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Oral semaglutide drops are suitable for people requiring smaller doses or who are not swallowing tablets

Causes: Steric hindrance from structural modifications Suboptimal digestion conditions Enzyme specificity limitations Impact: Missed cleavage sites Formation of larger, complex peptide fragments Reduced sequence coverage and mapping confidence 4